Tok J B, Fenker J
Department of Chemistry, York College and Graduate Center, The City University of New York, 94-20 Guy R. Brewer Blvd., Jamaica, NY 11451, USA.
Bioorg Med Chem Lett. 2001 Nov 19;11(22):2987-91. doi: 10.1016/s0960-894x(01)00602-3.
The synthesis and RNA-binding properties of naphthalene-based diimide conjugated bis-aminoglycoside antibiotics are reported. Compared to the monomeric aminoglycoside, the conjugated ligands were observed to attain up to 35-fold enhancement in binding affinity towards a novel RNA construct that contained two 16S rRNA A-sites.
报道了基于萘的二酰亚胺共轭双氨基糖苷类抗生素的合成及其RNA结合特性。与单体氨基糖苷相比，观察到共轭配体对含有两个16S rRNA A位点的新型RNA构建体的结合亲和力提高了35倍。
