外耳道色素沉着性鳞状细胞癌伴树枝状黑素细胞浸润

Pigmented squamous cell carcinoma with dendritic melanocyte colonization in the external auditory canal.

作者信息

Kamiya M, Maehara R, Iizuka S, Yoshida T, Yamanouchi H, Yokoo H, Sasaki A, Hirato J, Nakazato Y

机构信息

First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Pathol Int. 1999 Oct;49(10):909-12. doi: 10.1046/j.1440-1827.1999.00963.x.

DOI:10.1046/j.1440-1827.1999.00963.x

PMID:10571826

Abstract

A case of pigmented squamous cell carcinoma (SCC) with dendritic melanocyte colonization in the external auditory canal is reported and the previous cases are reviewed. A 65-year-old Japanese female was referred with a 7-year history of otitis. The patient also had a darkly pigmented 9 x 8 mm nodule in the external auditory canal. Microscopically, the tumor was SCC, but in some areas melanin pigments were found in the cytoplasm of the tumor cells. The tumor was thus diagnosed as pigmented SCC. As well as the tumor cells, dendritic-shaped cells colonized the tumor parenchyma and were immunohistochemically defined as melanocytes. The authors believe this is the first case of pigmented SCC with dendritic melanocyte colonization in the external auditory canal.

摘要

本文报告了一例外耳道色素沉着性鳞状细胞癌（SCC）伴树枝状黑素细胞浸润的病例，并对既往病例进行了回顾。一名65岁的日本女性因中耳炎病史7年前来就诊。患者外耳道还有一个9×8mm的深色色素沉着结节。显微镜下，肿瘤为鳞状细胞癌，但在某些区域肿瘤细胞的细胞质中发现了黑色素。因此，该肿瘤被诊断为色素沉着性鳞状细胞癌。除肿瘤细胞外，树枝状细胞浸润肿瘤实质，免疫组化鉴定为黑素细胞。作者认为这是首例外耳道色素沉着性鳞状细胞癌伴树枝状黑素细胞浸润的病例。