硫酸锌溶液灌肠可减轻大鼠实验性结肠炎的炎症。
Zinc sulphate solution enema decreases inflammation in experimental colitis in rats.
作者信息
Chen B W, Wang H H, Liu J X, Liu X G
机构信息
Department of Gastroenterology, First Teaching Hospital of Beijing Medical University, China.
出版信息
J Gastroenterol Hepatol. 1999 Nov;14(11):1088-92. doi: 10.1046/j.1440-1746.1999.02013.x.
BACKGROUND
It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.
METHODS
Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the first day of TNB colitis, the rats were treated with a zinc sulphate enema once daily for 6 days. The rats were examined 8 days later.
RESULTS
The TNB induced severe colitis as evidenced by increased mucosal lesion area, mucosal myeloperoxidase (MPO) activity and prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) levels. Six days after the application of the zinc sulphate enema, the mucosal lesion area, MPO activity, PGE2 and LTB4 levels all decreased significantly. Mucosal superoxide dismutase activity remained unchanged after zinc treatments.
CONCLUSIONS
Our data suggest that zinc sulphate enemas have an anti-inflammatory action on experimental colitis.
背景
据报道，硫酸锌在许多动物模型中具有抗炎作用；然而，锌在结肠炎中的影响仍不清楚。本研究的目的是探讨硫酸锌在实验性结肠炎中的作用。
方法
用2,4,6-三硝基苯磺酸（TNB）诱导大鼠结肠炎。从TNB诱导结肠炎的第一天开始，大鼠每天接受一次硫酸锌灌肠，共6天。8天后对大鼠进行检查。
结果
TNB诱导了严重的结肠炎，表现为黏膜损伤面积增加、黏膜髓过氧化物酶（MPO）活性以及前列腺素E2（PGE2）和白三烯B4（LTB4）水平升高。应用硫酸锌灌肠6天后，黏膜损伤面积、MPO活性、PGE2和LTB4水平均显著降低。锌处理后黏膜超氧化物歧化酶活性保持不变。
结论
我们的数据表明，硫酸锌灌肠对实验性结肠炎具有抗炎作用。
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