Lin H C, Ding H Y, Ko F N, Teng C M, Wu Y C
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Planta Med. 1999 Oct;65(7):595-9. doi: 10.1055/s-1999-14030.
Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD2 from arachidonic acid.
从芍药属植物中分离得到两种次要的苯乙酮，2,5 - 二羟基 - 4 - 甲氧基苯乙酮（2）和2,5 - 二羟基 - 4 - 甲基苯乙酮（7），它们能选择性抑制花生四烯酸诱导的兔血小板聚集。它们比主要化合物丹皮酚（1）更有效，并且7还能抑制花生四烯酸生成血栓素A2（TXA2）和前列腺素D2（PGD2）。
