Macintosh D J, Price C H, Jeffree G M
J Bone Joint Surg Br. 1975 Aug;57(3):331-40.
Forty-seven histologically confirmed cases of Ewing's tumour are reported, with typical age, sex and skeletal distributions. The disease-free survival curves are like those for osteosarcoma of corresponding types of bone, but with higher mortality. The two-year disease-free survival rates were 24 percent for tumours of long bones and 5 per cent for those of other bones. Osseous metastases were most frequent, although the lung was the commonest single site involved. There were secondary deposits in lymph nodes in nine patients, possibly also in four more with mediastinal enlargement. Although initially radiosensitive, one-third of tumours recurred locally, almost always with the appearance of metastases. Neither whole bone irradiation nor high dosage alone ensures complete control of the primary tumour, and it is suggested that recently reported improved results of treatment should be attributed to adjuvant multi-drug chemotherapy. Inadequate control of the primary tumour diminishes the chance of survival and for some sites radical operation merits reconsideration.
报告了47例经组织学确诊的尤因肉瘤病例，具有典型的年龄、性别和骨骼分布情况。无病生存曲线与相应类型骨骨肉瘤的曲线相似，但死亡率更高。长骨肿瘤的两年无病生存率为24%，其他骨肿瘤为5%。骨转移最为常见，尽管肺部是最常受累的单一部位。9例患者有淋巴结继发性沉积，另外4例纵隔增宽患者可能也有。尽管肿瘤最初对放疗敏感，但三分之一的肿瘤会局部复发，几乎总是伴有转移出现。单纯全骨照射或高剂量照射都不能确保完全控制原发性肿瘤，有人认为最近报道的治疗效果改善应归因于辅助多药化疗。对原发性肿瘤控制不充分会降低生存机会，对于某些部位，根治性手术值得重新考虑。
