Roh C R, Lee B L, Oh W J, Whang J D, Choi D S, Yoon B K, Lee J H
Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Korean Med Sci. 1999 Oct;14(5):552-8. doi: 10.3346/jkms.1999.14.5.552.
To elucidate the endocrine mechanism of human parturition, the expression of c-Jun and c-Fos mRNA were examined in relation to estrogen receptor (ER) and progesterone receptor (PR) in human myometrium. c-Jun mRNA was detected in all myometrial tissues (n=5) during labor but not before labor (n=5) and in oxytocin-resistant postterm pregnancy (n=3). c-Fos mRNA was detected in only one myometrial tissue from a woman in labor. The distribution and intensity of immunostaining for ER and PR were semiquantitatively scored. During the late pregnancies, no significant difference was seen in the receptor scores for myometrial ER and PR between the patients who experienced labor and those who did not. Receptor scores for ER and PR were significantly lower in postterm pregnancy than in late pregnancy, regardless of the labor status. These data suggest that there are no changes in ER and PR in human myometrium during parturition. On the other hand, postterm pregnancy is associated with low ER and PR. c-Jun, induced during labor without changes in ER and PR, may play a role as a signaling mechanism in human myometrium.
为阐明人类分娩的内分泌机制，研究了人子宫肌层中c-Jun和c-Fos mRNA的表达与雌激素受体（ER）和孕激素受体（PR）的关系。在分娩期间的所有子宫肌层组织（n = 5）中均检测到c-Jun mRNA，但在分娩前（n = 5）以及过期妊娠且对催产素耐药的患者（n = 3）中未检测到。仅在一名分娩女性的一个子宫肌层组织中检测到c-Fos mRNA。对ER和PR免疫染色的分布和强度进行了半定量评分。在妊娠晚期，经历分娩的患者与未经历分娩的患者之间，子宫肌层ER和PR的受体评分未见显著差异。无论分娩状态如何，过期妊娠时ER和PR的受体评分均显著低于妊娠晚期。这些数据表明，分娩期间人子宫肌层中的ER和PR没有变化。另一方面，过期妊娠与低ER和PR相关。在分娩期间诱导产生的c-Jun，在ER和PR无变化的情况下，可能在人子宫肌层中作为一种信号机制发挥作用。
