Simark-Mattsson C, Jontell M, Bergenholtz G, Dahlgren U I
Department of Endodontology/Oral Diagnosis, Faculty of Odontology, Göteborg, Sweden.
J Dent Res. 1999 Nov;78(11):1704-10. doi: 10.1177/00220345990780110701.
Oral lichen planus is considered to be a T-cell-mediated disease. The purpose of this study was to investigate the capacity of T-lymphocytes in oral lichen planus patients to respond to a number of commonly encountered environmental antigens in vivo. To do this, we assessed dermal delayed-type hypersensitivity responses to mumps, streptokinase/streptodornase, Candida albicans, and purified protein derivative of tuberculin (PPD) in 17 oral lichen planus patients and in matched controls. Reduced induration in response toward mumps, PPD, and streptokinase/streptodornase was demonstrated in oral lichen planus patients compared with controls. In addition, the total sum of induration diameters was decreased in the patients. However, C. albicans stimulation resulted in similar levels of response in both groups. The differences in induration size between matched patients and controls for mumps and PPD were thus significantly greater than the corresponding differences for the C. albicans antigen. This suggests that a selective difference in the response to these antigens exists in oral lichen planus patients. The results may point to a loss of memory T-helper function to infrequently encountered environmental antigens, represented by mumps, PPD, and streptokinase/streptodornase, contrarily to memory function to common antigens (C. albicans), which seem to be unaffected.
口腔扁平苔藓被认为是一种T细胞介导的疾病。本研究的目的是调查口腔扁平苔藓患者体内T淋巴细胞对多种常见环境抗原的应答能力。为此，我们评估了17例口腔扁平苔藓患者及匹配对照对腮腺炎、链激酶/链道酶、白色念珠菌和结核菌素纯蛋白衍生物（PPD）的皮肤迟发型超敏反应。与对照组相比，口腔扁平苔藓患者对腮腺炎、PPD和链激酶/链道酶的硬结反应减弱。此外，患者硬结直径的总和也降低。然而，白色念珠菌刺激在两组中引起的反应水平相似。因此，匹配患者和对照之间腮腺炎和PPD硬结大小的差异明显大于白色念珠菌抗原的相应差异。这表明口腔扁平苔藓患者对这些抗原的反应存在选择性差异。结果可能表明，对腮腺炎、PPD和链激酶/链道酶所代表的不常见环境抗原的记忆性T辅助功能丧失，而对常见抗原（白色念珠菌）的记忆功能似乎未受影响。
