细胞因子与JAK-STAT信号传导

Cytokines and JAK-STAT signaling.

作者信息

Schindler C

机构信息

Columbia University, 701 W. 168th Street, HHSC-1212, New York, New York, 10032, USA.

出版信息

Exp Cell Res. 1999 Nov 25;253(1):7-14. doi: 10.1006/excr.1999.4670.

DOI:10.1006/excr.1999.4670

PMID:10579906

Abstract

Characterization of the ability of IFNs to induce immediate early genes led to the identification of the STAT (signal transducers and activators of transcription) signaling paradigm. STATs are activated at the receptor and then directly transduce signals to the nucleus. Subsequent studies have determined that all cytokines transduce critical signals through this pathway.

摘要

对干扰素诱导即刻早期基因能力的表征导致了STAT（信号转导子和转录激活子）信号转导模式的发现。STATs在受体处被激活，然后直接将信号转导至细胞核。随后的研究确定，所有细胞因子都通过该途径转导关键信号。