Horvath Curt M
Department of Medicine, Evanston Northwestern Healthcare Research Institute, IL 60208, USA.
Sci STKE. 2004 Nov 23;2004(260):tr9. doi: 10.1126/stke.2602004tr9.
Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by a variety of growth-regulating signals as well as diverse cytokines that use gp130 signaling receptors. STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune regulatory and homeostatic functions. The animation shows activation of STAT3 in response to interleukin 6 (IL6), a cytokine involved in triggering inflammation.
信号转导与转录激活因子3（STAT3）广泛表达，并被多种生长调节信号以及使用gp130信号受体的多种细胞因子激活。STAT3对胚胎发育、干细胞生物学以及炎症、生长调节和多种免疫调节及稳态功能至关重要。该动画展示了STAT3对白细胞介素6（IL6）的响应激活过程，白细胞介素6是一种参与引发炎症的细胞因子。
