Bruce A W, Mahan D E
Can Med Assoc J. 1978 Nov 4;119(9):1077-84.
Adenocarcinoma of the prostate is responsible for one of every nine deaths from cancer in Canada. In this review epidemiologic factors are considered and current staging systems are outlined. The American Urological System is recommended for staging because of its ability to reflect changes in the understanding of the biologic behaviour of this neoplasm. The adoption of a quantitative grading scheme is suggested to complement the information obtained from the staging assessment. The routes of spread of this disease, along with the procedures used to assess metastatic involvement, are described. Immunologic methods for the analysis of prostatic acid phosphatase have been shown to be superior to the enzymatic methods previously used, and the role of the new techniques is discussed. Emphasis is placed on radiotherapy and endocrine therapy for the treatment of this neoplasm, and the concept of withholding endocrine therapy until symptoms appear is discussed. Potential future developments in this field are considered.
前列腺癌是加拿大每九例癌症死亡病例中的病因之一。本综述探讨了流行病学因素，并概述了当前的分期系统。由于美国泌尿外科学会系统能够反映对该肿瘤生物学行为认识的变化，因此推荐使用该系统进行分期。建议采用定量分级方案，以补充分期评估所获得的信息。本文描述了该疾病的传播途径以及用于评估转移累及情况的方法。已证明免疫分析法检测前列腺酸性磷酸酶优于先前使用的酶法，并对这些新技术的作用进行了讨论。重点讨论了前列腺癌的放射治疗和内分泌治疗，以及关于在症状出现之前不进行内分泌治疗的理念。同时也考虑了该领域未来可能的发展。
