Hogan D F, Dhaliwal R S, Sisson D D, Kitchell B E
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61802, USA.
J Am Anim Hosp Assoc. 1999 Nov-Dec;35(6):483-6. doi: 10.5326/15473317-35-6-483.
A six-year-old cat presented with clinical signs consistent with distal aortic thromboembolism while clinical signs of cardiovascular disease were absent. Diagnostics, including thoracic radiographs, electrocardiography, and echocardiography revealed no cardiovascular anomalies. Thoracic radiographs revealed multifocal pulmonary lesions consistent with neoplasia. Complete blood cell count demonstrated a marked thrombocytosis, leukopenia, and neutropenia. Histopathology of the pulmonary lesions confirmed multiple bronchoalveolar carcinomas. Myelodysplasia with megakaryocytic hyperplasia and ineffective myelopoiesis was noted on bone-marrow histopathology from multiple sites. The absence of other causes suggested a paraneoplastic thrombocytosis. The diagnosis of paraneoplastic thrombocytosis-induced thromboembolism was made due to the lack of underlying cardiac disease and the presence of a marked thrombocytosis. The presence of thrombocytosis and thromboembolism associated with neoplasia is discussed.
一只六岁的猫出现了与远端主动脉血栓栓塞相符的临床症状，而无心血管疾病的临床症状。包括胸部X光片、心电图和超声心动图在内的诊断检查未发现心血管异常。胸部X光片显示多灶性肺部病变，与肿瘤相符。全血细胞计数显示明显的血小板增多、白细胞减少和中性粒细胞减少。肺部病变的组织病理学证实为多发性支气管肺泡癌。多处骨髓组织病理学检查发现骨髓发育异常伴巨核细胞增生和无效造血。排除其他病因后提示为副肿瘤性血小板增多症。由于缺乏潜在的心脏疾病且存在明显的血小板增多症，故诊断为副肿瘤性血小板增多症所致的血栓栓塞。本文讨论了与肿瘤相关的血小板增多症和血栓栓塞的存在情况。
