Fedorov A A, Kurenkov V V, Kasparov A A, Polunin G S
Vestn Oftalmol. 1999 Sep-Oct;115(5):26-8.
Morphological characteristics of the haze [correction of fleur] (subepithelial corneal opacity) observed after photorefraction interventions are described. Early haze [correction of fleur] (during the first 14 days) is caused by structural and spatial disorders and edema of the surface stromal layers under the hyperplastic epithelium. By its pattern and localization it can be classified as early subepithelial exudative. With differentiation of the epithelium and restructuring of the extracellular matrix, early haze [correction of fleur] as a rule gradually and spontaneously resolves within 10-14 days. Late haze [correction of fleur] is more stable and stubborn; it develops as a result of proliferation and migration of activated keratocytes into surface layers of the stroma at the site of photoablation usually 3 months and more after photorefraction keratectomy. Therefore, exposure of the cornea to an eximer laser is a source of its exogenous (physical) injury leading to an aseptic inflammation. The task of the refraction surgeon is timely drug correction, adequate to phases of inflammation, in order to create conditions for rapid complete regeneration of corneal tissue and restoration of its transparency.
描述了屈光性手术干预后观察到的雾状混浊（上皮下角膜混浊）的形态学特征。早期雾状混浊（在最初14天内）是由增生上皮下表面基质层的结构和空间紊乱以及水肿引起的。根据其形态和定位，可将其分类为早期上皮下渗出性混浊。随着上皮的分化和细胞外基质的重构，早期雾状混浊通常在10 - 14天内逐渐自发消退。晚期雾状混浊更稳定且顽固；它是由于活化的角膜细胞在光凝部位增殖并迁移到基质表层而形成的，通常在屈光性角膜切削术后3个月及更长时间出现。因此，角膜暴露于准分子激光是其外源性（物理性）损伤的来源，导致无菌性炎症。屈光手术医生的任务是根据炎症阶段及时进行药物矫正，以创造条件促进角膜组织快速完全再生并恢复其透明度。
