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在调节θ节律的结构功能被排除的情况下,兔海马神经元的背景活动

Background activity of rabbit hippocampal neurons in conditions of functional exclusion of structures which regulate the theta rhythm.

作者信息

Kichigina V F, Kudina T A, Zenchenko K I, Vinogradova O S

机构信息

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.

出版信息

Neurosci Behav Physiol. 1999 Jul-Aug;29(4):377-84. doi: 10.1007/BF02461072.

Abstract

The functional importance of theta modulation in the activity of hippocampal neurons was further analyzed using a method consisting of controlled sequential short-term (25-30 min) inclusion or exclusion of the theta rhythm by local administration of lidocaine into the median cervical nucleus and medial septal region respectively. Studies were carried out using conscious rabbits with extracellular recording of hippocampal neuron activity in field CA1. Administration of lidocaine into the medial septal nucleus and diagonal tract nucleus (MS-DT) led to complete inhibition of theta modulation in neuronal and total hippocampus activity. The mean frequency of background discharges underwent no change in most neurons, but decreased significantly in a limited group of cells with high-frequency activity (presumptive inhibitory neurons). Administration of lidocaine into the median cervical nucleus (MCN), the source of serotoninergic pathways to the MS-DT and hippocampus, was accompanied by increases in the stability and frequency of theta modulation of neuronal activity, induction of theta modulation in an additional group of neurons, and expression of a continuous theta rhythm in the electrical activity (EA) of the hippocampus. The mean frequency and regularity of discharges increased in most cells. These data support the existence of tonic inhibitory effects on the part of the MCN on the septa-hippocampal system generating the theta rhythm; in this regard, the MCN can be regarded as an antagonist of the activating reticular formation.

摘要

通过一种方法进一步分析了海马神经元活动中θ调制的功能重要性,该方法包括分别向颈正中核和内侧隔区局部注射利多卡因,以控制性地顺序短期(25 - 30分钟)包含或排除θ节律。研究在清醒兔身上进行,对CA1区海马神经元活动进行细胞外记录。向内侧隔核和斜角带核(MS - DT)注射利多卡因导致神经元和整个海马活动中的θ调制完全抑制。大多数神经元的背景放电平均频率没有变化,但在一小部分高频活动细胞(推测为抑制性神经元)中显著降低。向颈正中核(MCN)注射利多卡因,MCN是向MS - DT和海马提供5-羟色胺能通路的源头,这伴随着神经元活动θ调制的稳定性和频率增加、另一组神经元中θ调制的诱导以及海马电活动(EA)中连续θ节律的表达。大多数细胞的放电平均频率和规律性增加。这些数据支持MCN对产生θ节律的隔 - 海马系统存在紧张性抑制作用;在这方面,MCN可被视为激活网状结构的拮抗剂。

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