Cassel J C, Jeltsch H
Université Louis Pasteur, URA 1939 du CNRS, Strasbourg, France.
Neuroscience. 1995 Nov;69(1):1-41. doi: 10.1016/0306-4522(95)00241-a.
Accumulating evidence suggests that serotonin may modulate cholinergic function in several regions of the mammalian brain and that these serotonergic/cholinergic interactions influence cognition. The first part of this review is an overview of histological, electrophysiological and pharmacological (in vitro, in vivo) data indicating that, in several brain regions (e.g., hippocampus, cortex and striatum), there are neuroanatomical substrates for a serotonergic/cholinergic interaction, and that alterations in serotonergic activity may induce functional changes in cholinergic neurons. In the second part, the review focuses on experimental approaches showing or suggesting that central cholinergic and serotonergic mechanisms are cooperating in the regulation of cognitive functions. These arguments are based on lesion, intracerebral grafting and pharmacological techniques. It is concluded that not all mnesic perturbations induced by concurrent manipulations of the serotonergic and cholinergic systems can be attributed to a serotonergic modification of the cholinergic system. The cognitive faculties of an organism arise from interactions among several neurotransmitter systems within brain structures such as, for instance, the hippocampus or the cortex, but also from influences on memory of other general functions that may involve cerebral substrates different from those classically related to mnesic functions (e.g., attention, arousal, sensory accuracy, etc.).
越来越多的证据表明，血清素可能会调节哺乳动物大脑多个区域的胆碱能功能，并且这些血清素能/胆碱能相互作用会影响认知。本综述的第一部分概述了组织学、电生理学和药理学（体外、体内）数据，这些数据表明，在几个脑区（如海马体、皮层和纹状体）中，存在血清素能/胆碱能相互作用的神经解剖学基础，并且血清素能活性的改变可能会诱导胆碱能神经元的功能变化。在第二部分中，综述聚焦于表明或暗示中枢胆碱能和血清素能机制在认知功能调节中相互协作的实验方法。这些论据基于损伤、脑内移植和药理学技术。得出的结论是，并非所有由同时操纵血清素能和胆碱能系统所引起的记忆障碍都可归因于胆碱能系统的血清素能修饰。生物体的认知能力源于大脑结构（如海马体或皮层）内多个神经递质系统之间的相互作用，也源于对记忆的其他一般功能的影响，这些功能可能涉及与经典记忆功能不同的脑底物（如注意力、觉醒、感觉准确性等）。
