Park S H, Ostrzega N, Akers M A, Vinters H V
Department of Pathology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
Ultrastruct Pathol. 1999 Sep-Oct;23(5):311-7. doi: 10.1080/019131299281455.
A case is reported of intraventricular neurocytoma that had characteristic light microscopic findings of neurocytoma with prominent intracytoplasmic concentric lamellar structures mimicking myelin sheaths. On routine H&E-stained sections, this tumor showed intracytoplasmic vesicular bleb-like structures having eosinophilic cores that were consistent with ultrastructural concentric lamellar structures. Immunohistochemically, this tumor was immunoreactive for synaptophysin and neurofilament, but negative for antibody to glial fibriallary acidic protein. Electron microscopic findings fulfilled the criteria for neurocytoma, with the presence of neurosecretory granules and neurotubules. These findings may suggest dual differentiation of this tumor into neurocytes and oligodendrocytes.
报告了一例脑室内神经细胞瘤，其具有神经细胞瘤典型的光镜下表现，有突出的胞浆内同心层状结构，类似髓鞘。在常规苏木精-伊红染色切片上，该肿瘤显示胞浆内有含嗜酸性核心的泡状小泡样结构，与超微结构的同心层状结构一致。免疫组化显示，该肿瘤对突触素和神经丝呈免疫反应，但对胶质纤维酸性蛋白抗体呈阴性。电镜检查结果符合神经细胞瘤的标准，存在神经分泌颗粒和神经微管。这些发现可能提示该肿瘤向神经细胞和少突胶质细胞的双向分化。
