Njoo M D, Bossuyt P M, Westerhof W
Netherlands Institute for Pigmentary Disorders, IWO Building, Academic Medical Center, Amsterdam.
Int J Dermatol. 1999 Nov;38(11):866-72. doi: 10.1046/j.1365-4362.1999.00822.x.
Several therapeutic options are available for the treatment of vitiligo. Concern exists that there is no uniform approach towards the management of vitiligo among Dutch dermatologists.
A written survey concerning the management of vitiligo was sent to 332 dermatologists in The Netherlands.
The response rate was 86%. "Giving information and reassurance concerning the nature of disease" was regarded by most dermatologists (68%) as being the most important goal in the management of vitiligo. Only 16% of the dermatologists aimed for active treatment in vitiligo. The reported therapy choices in children resembled those of adults, except that slightly more dermatologists did not prescribe active therapy in children. Nine different therapeutic modalities were mentioned as first choice therapies. Topical corticosteroids were indicated by most dermatologists as first choice therapy (241 out of 266, i.e. 91%); however, only 2% indicated that 50% or more of the patients achieved a successful treatment; 66% found that less than 25% of the patients were successfully treated with topical corticosteroids. Only 15% of the respondents reported that 50% or more of the patients were treated successfully with narrow-band UVB. The observed response profile to broad-band UVB therapy was found to be comparable with that of narrow-band UVB. The classical therapy with oral psoralen plus UVA (PUVA) was prescribed as first choice therapy by only 12% (32 out of 266) of the dermatologists. Only 6% of these respondents observed that 50% or more of the patients achieved successful therapy using oral PUVA. The recommended maximum treatment duration for topical corticosteroids, oral PUVA, and UVB therapy was found to vary from 3 to 12 months.
Most dermatologists in The Netherlands do not offer active treatment in vitiligo, probably because the estimated effectiveness of (nonsurgical) repigmentation therapy is low. In cases where treatment is prescribed, there appears to be no consensus on the choice of therapies and treatment strategies. The development of practice guidelines may be helpful in reducing inappropriate care and improving treatment outcome.
白癜风的治疗有多种选择。荷兰皮肤科医生在白癜风的管理上缺乏统一方法,这引发了人们的担忧。
向荷兰的332名皮肤科医生发送了一份关于白癜风管理的书面调查问卷。
回复率为86%。大多数皮肤科医生(68%)认为“提供关于疾病本质的信息并给予安慰”是白癜风管理中最重要的目标。只有16%的皮肤科医生旨在积极治疗白癜风。报告的儿童治疗选择与成人相似,只是略多一些皮肤科医生不给儿童开积极的治疗药物。九种不同的治疗方式被提及为首选疗法。大多数皮肤科医生将外用皮质类固醇作为首选疗法(266名中有241名,即91%);然而,只有2%的医生表示50%或更多患者治疗成功;66%的医生发现不到25%的患者外用皮质类固醇治疗成功。只有15%的受访者报告50%或更多患者窄谱中波紫外线治疗成功。发现宽谱中波紫外线治疗的观察反应情况与窄谱中波紫外线治疗相当。只有12%(266名中有32名)的皮肤科医生将口服补骨脂素加紫外线A(PUVA)的经典疗法作为首选疗法。这些受访者中只有6%观察到50%或更多患者口服PUVA治疗成功。外用皮质类固醇、口服PUVA和紫外线治疗的推荐最大治疗时长为3至12个月。
荷兰的大多数皮肤科医生不提供白癜风的积极治疗,可能是因为(非手术)色素再生疗法的估计疗效较低。在开出处方治疗的情况下,治疗方法和治疗策略的选择似乎没有共识。制定实践指南可能有助于减少不适当的治疗并改善治疗结果。