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大疱性类天疱疮治疗方法的当前实践:荷兰与英国全国性调查的比较

Current practice in treatment approach for bullous pemphigoid: comparison between national surveys from the Netherlands and the UK.

作者信息

Meijer J M, Jonkman M F, Wojnarowska F, Wiliams H C, Kirtschig G

机构信息

Department of Dermatology, Center for Skin Blistering Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

出版信息

Clin Exp Dermatol. 2016 Jul;41(5):506-9. doi: 10.1111/ced.12831. Epub 2016 Mar 4.

Abstract

Treatment approaches for bullous pemphigoid (BP), the most common autoimmune skin blistering disease, are largely based on national and international guidelines. We conducted a national survey among dermatologists in the Netherlands to explore the current treatment of BP, and compared the results with those of a previously published survey from the UK. Almost all responders in the Netherlands (n = 175) used very potent topical corticosteroids, both as monotherapy and as adjunctive therapy. In contrast to UK dermatologists, the majority recommended whole-body application rather than local application to lesions. Systemic antibiotics were used by > 70% of responders. Half of the responders in the Netherlands considered systemic steroids the first-choice treatment, with the majority also using adjunctive therapy as a routine. Despite many similarities in treatment approach between the two countries, these surveys provide an important insight into the gap between actual and recommended practice at a country level in relation to the best external evidence.

摘要

大疱性类天疱疮(BP)是最常见的自身免疫性皮肤水疱病,其治疗方法很大程度上基于国家和国际指南。我们在荷兰的皮肤科医生中进行了一项全国性调查,以探究BP的当前治疗情况,并将结果与英国之前发表的一项调查结果进行比较。荷兰几乎所有的受访者(n = 175)都使用超强效外用糖皮质激素,既作为单一疗法,也作为辅助疗法。与英国皮肤科医生不同的是,大多数人推荐全身应用而非局部应用于皮损。超过70%的受访者使用了全身性抗生素。荷兰一半的受访者认为全身性类固醇是首选治疗方法,大多数人也将辅助疗法作为常规使用。尽管两国在治疗方法上有许多相似之处,但这些调查为了解国家层面实际做法与基于最佳外部证据的推荐做法之间的差距提供了重要见解。

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