Raabe D S
Chest. 1979 Feb;75(2):152-6. doi: 10.1378/chest.75.2.152.
Three patients with variant angina pectoris resistant to therapy with nitrates and propranolol were treated with perhexilene maleate. Two patients had normal coronary arteries with documented coronary artery spasm, while the third patient had a fixed coronary artery obstruction. In all three patients, attacks of variant angina pectoris disappeared following institution of therapy with perhexilene maleate. When the dose of this drug was decreased to 100 mg per day or less, symptoms reappeared in all patients. Reinstitution of therapeutic doses of perhexilene maleate once again resulted in complete control of symptoms. Perhexilene maleate is therefore a useful agent for the treatment of variant angina pectoris.
三名对硝酸盐和普萘洛尔治疗无效的变异型心绞痛患者接受了马来酸哌克昔林治疗。两名患者冠状动脉正常，但有冠状动脉痉挛的记录，而第三名患者有固定的冠状动脉阻塞。在所有三名患者中，使用马来酸哌克昔林治疗后，变异型心绞痛发作消失。当该药剂量降至每日100毫克或更低时，所有患者症状再次出现。重新使用治疗剂量的马来酸哌克昔林再次完全控制了症状。因此，马来酸哌克昔林是治疗变异型心绞痛的一种有用药物。
