Yokomori T, Iesato H, Kamoshita N, Nagaoka H, Okabe T, Kato Y
Dept. of Surgery, Ojiya General Hospital.
Gan To Kagaku Ryoho. 1999 Nov;26(13):2043-8.
Combination chemotherapy with multiple drugs (FLMP therapy), in which the drugs were determined based on biochemical modulation and the dosing schedule was established in accordance with the circadian rhythms of the human body, was performed in cases of advanced recurrent gastric cancer. The drugs were administered according to the following schedule: 500 mg of 5-FU (continuous) on days 1-5 (the dose was increased during the night), 20 mg of LV on days 1-5 (at 6 PM), 2 mg of MMC on day 5 (at 9 AM) and 60-80 mg of CDDP on day 5 (at 6 PM). A five-day course was administered by intravenous drip or hepatic arterial infusion at intervals of 4 weeks. Of 14 patients treated, the effect was estimated to be CR in 3, PR in 6, NC in 3, and PD in 2. The effectiveness rate was 62.3% overall, and the rate by administration route was 6/10 (60.0%) for i.v. and 3/4 (75.0%) for i.a. The side effects were slight. Those of grade 3 or more included anorexia in 5%, nausea and vomiting in 1%, stomatitis in 1% and leukopenia in 1%. This therapy, administered in accordance with the theory of chronotherapy, caused few side effects, and thus is considered a promising treatment for gastric cancer.
对晚期复发性胃癌患者采用了多药联合化疗（FLMP疗法），其中药物根据生化调节确定，给药方案根据人体昼夜节律制定。给药方案如下：第1 - 5天持续给予500mg 5 - FU（夜间剂量增加），第1 - 5天下午6点给予20mg亚叶酸钙，第5天上午9点给予2mg丝裂霉素，第5天下午6点给予60 - 80mg顺铂。每4周进行一次为期5天的疗程，通过静脉滴注或肝动脉灌注给药。在接受治疗的14例患者中，评估效果为完全缓解（CR）3例，部分缓解（PR）6例，疾病稳定（NC）3例，疾病进展（PD）2例。总体有效率为62.3%，按给药途径计算，静脉注射有效率为6/10（60.0%），肝动脉灌注有效率为3/4（75.0%）。副作用轻微。3级及以上副作用包括5%的患者出现厌食，1%的患者出现恶心和呕吐，1%的患者出现口腔炎，1%的患者出现白细胞减少。这种根据时间治疗理论进行的治疗副作用较少，因此被认为是一种有前景的胃癌治疗方法。
