Garcia C A
Tulane University Medical Center, Department of Psychiatry and Neurology, New Orleans, Louisiana 70112-2715, USA.
Ann N Y Acad Sci. 1999 Sep 14;883:69-76.
CMT polyneuropathy is a complex genetically and clinically heterogeneous group of disorders. The rapid advances in our understanding of the molecular basis of these groups of neuropathies have helped to resolve some of the controversial issues regarding the clinical and genetic classification. However, there is still confusion and chaos in the terminology employed by different groups of researchers. A reclassification based on the molecular mechanisms of these neuropathies will help in the future to unify and simplify the diagnosis of these complex disorders. The understanding of the molecular mechanisms will also help in the future to find a way to control or treat these hereditary neuropathies.
遗传性运动感觉性多发性神经病（CMT）是一组在遗传和临床方面具有复杂性且异质性的疾病。我们对这些神经病组分子基础认识的迅速进展，有助于解决一些关于临床和遗传分类的争议问题。然而，不同研究团队所采用的术语仍存在混淆和混乱。基于这些神经病分子机制的重新分类，未来将有助于统一和简化这些复杂疾病的诊断。对分子机制的理解在未来也将有助于找到控制或治疗这些遗传性神经病的方法。
