Can Fam Physician. 1999 Nov;45:2626-8, 2630-3.
Valsartan (Diovan) is an antihypertensive drug belonging to the family of angiotensin II receptor antagonists. At a dose of 40 mg/d, its antihypertensive effect is inconsistent. At 80 mg/d its effect on blood pressure, its adverse effects, and its contraindications (mainly pregnancy and renal artery stenosis) are similar to those of angiotensin-converting enzyme (ACE) inhibitors, except that coughing is rarer with valsartan than with ACE inhibitors. Valsartan has no demonstrated advantage over losartan, another angiotensin II antagonist. Valsartan has not been shown to prevent complications of arterial hypertension, and its use is, therefore, less well validated than that of diuretics and beta-blockers.
缬沙坦（代文）是一种属于血管紧张素II受体拮抗剂类别的抗高血压药物。剂量为40毫克/天时，其降压效果不一致。剂量为80毫克/天时，其对血压的作用、不良反应及禁忌证（主要是妊娠和肾动脉狭窄）与血管紧张素转换酶（ACE）抑制剂相似，只是缬沙坦引起咳嗽比ACE抑制剂少见。缬沙坦与另一种血管紧张素II拮抗剂氯沙坦相比并无已证实的优势。缬沙坦尚未显示出可预防动脉高血压并发症，因此，其应用的有效性不及利尿剂和β受体阻滞剂。
