加替沙星对沙眼衣原体和肺炎衣原体的体外活性。

In-vitro activity of gatifloxacin against Chlamydia trachomatis and Chlamydia pneumoniae.

作者信息

Roblin P M, Hammerschlag M R

机构信息

Department of Pediatrics, State University of New York, Health Science Center at Brooklyn, 11203, USA.

出版信息

J Antimicrob Chemother. 1999 Oct;44(4):549-51. doi: 10.1093/jac/44.4.549.

DOI:10.1093/jac/44.4.549

PMID:10588319

Abstract

We compared the activity of gatifloxacin, a new quinolone, ofloxacin and erythromycin against five isolates of Chlamydia trachomatis and 20 isolates of Chlamydia pneumoniae, including TW183 and clinical isolates from the USA and Japan. Testing was done in cycloheximide-treated HEp-2 cells. Gatifloxacin was slightly less active against C. trachomatis and slightly more active against C. pneumoniae than ofloxacin, with MICs at which 90% of the isolates had no inclusions and minimal chlamydicidal concentrations at which 90% of the isolates had no inclusions after passage of 0.25 mg/L. Gatifloxacin was less active than erythromycin for both species.

摘要

我们比较了新型喹诺酮类药物加替沙星、氧氟沙星和红霉素对5株沙眼衣原体及20株肺炎衣原体（包括TW183以及来自美国和日本的临床分离株）的活性。检测在经放线菌酮处理的HEp-2细胞中进行。与氧氟沙星相比，加替沙星对沙眼衣原体的活性略低，对肺炎衣原体的活性略高，其使90%的分离株无包涵体的最低抑菌浓度（MIC）以及在0.25mg/L传代后使90%的分离株无包涵体的最低杀衣原体浓度。加替沙星对这两种衣原体的活性均低于红霉素。