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本文引用的文献

1
Concentrations of gatifloxacin in plasma and urine and penetration into prostatic and seminal fluid, ejaculate, and sperm cells after single oral administrations of 400 milligrams to volunteers.对志愿者单次口服400毫克加替沙星后，其血浆、尿液中的药物浓度以及药物向前列腺液、精液、射精液和精子细胞中的渗透情况。
Antimicrob Agents Chemother. 2001 Jan;45(1):293-7. doi: 10.1128/AAC.45.1.293-297.2001.
2
Clinical pharmacology of gatifloxacin, a new fluoroquinolone.新型氟喹诺酮类药物加替沙星的临床药理学
Clin Infect Dis. 2000 Aug;31 Suppl 2:S51-8. doi: 10.1086/314061.
3
Antimycobacterial activities of novel levofloxacin analogues.新型左氧氟沙星类似物的抗分枝杆菌活性
Antimicrob Agents Chemother. 2000 Aug;44(8):2126-9. doi: 10.1128/AAC.44.8.2126-2129.2000.
4
A dose-escalation study of the safety, tolerability, and pharmacokinetics of intravenous gatifloxacin in healthy adult men.一项关于健康成年男性静脉注射加替沙星安全性、耐受性及药代动力学的剂量递增研究。
Pharmacotherapy. 2000 Jun;20(6 Pt 2):49S-58S. doi: 10.1592/phco.20.8.49s.35186.
5
Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid.左氧氟沙星在人皮肤水疱液中对肺炎链球菌和金黄色葡萄球菌的药代动力学和药效学
Antimicrob Agents Chemother. 2000 May;44(5):1352-5. doi: 10.1128/AAC.44.5.1352-1355.2000.
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In-vitro activity of gatifloxacin against Chlamydia trachomatis and Chlamydia pneumoniae.加替沙星对沙眼衣原体和肺炎衣原体的体外活性。
J Antimicrob Chemother. 1999 Oct;44(4):549-51. doi: 10.1093/jac/44.4.549.
7
A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose.
J Antimicrob Chemother. 1999 Nov;44(5):701-4. doi: 10.1093/jac/44.5.701.
8
Gatifloxacin.加替沙星
Drugs. 1999 Oct;58(4):683-96; discussion 697-8. doi: 10.2165/00003495-199958040-00010.
9
In vitro activities of gatifloxacin, two other quinolones, and five nonquinolone antimicrobials against obligately anaerobic bacteria.加替沙星、另外两种喹诺酮类药物以及五种非喹诺酮类抗菌药物对专性厌氧菌的体外活性
Antimicrob Agents Chemother. 1999 Nov;43(11):2783-6. doi: 10.1128/AAC.43.11.2783.
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In-vitro activity of gatifloxacin, a novel fluoroquinolone, compared with that of ciprofloxacin against Legionella spp.新型氟喹诺酮类药物加替沙星与环丙沙星对军团菌属的体外活性比较
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加替沙星在富含粒细胞的渗出物中对肺炎链球菌和金黄色葡萄球菌的药代动力学和药效学

Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate.

作者信息

Trampuz Andrej, Laifer Gerd, Wenk Markus, Rajacic Zarko, Zimmerli Werner

机构信息

Division of Infectious Diseases, Departments of Internal Medicine and Research, University Hospitals, Basel, Switzerland.

出版信息

Antimicrob Agents Chemother. 2002 Nov;46(11):3630-3. doi: 10.1128/AAC.46.11.3630-3633.2002.

DOI:10.1128/AAC.46.11.3630-3633.2002
PMID:12384378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC128756/
Abstract

The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

摘要

对加替沙星在血清和皮肤水疱液（SBF）中的药代动力学进行了评估，同时也评估了其在SBF中的药效学活性。单剂量给予加替沙星5小时后，在体外2小时孵育期间，SBF可杀死2.5个对数的肺炎链球菌和1.5个对数的金黄色葡萄球菌。