Levy R, Herzberg G R
Department of Biochemistry, Memorial University, St. John's NF, Canada.
Can J Physiol Pharmacol. 1999 Oct;77(10):813-8.
The hydrolysis of chylomicrons enriched in long-chain n-3 fatty acids by cardiac lipoprotein lipase was studied. In 60 min, 24.8% of the triacylglycerol fatty acids were released as free fatty acids. The fatty acids were hydrolyzed at different rates. DHA (docosahexaenoic acid, 22:6n-3) and EPA (eicosapentaenoic acid, 20:5n-3) were released at rates significantly less than average. Stearic acid (18:0), 20:1n-9, and alpha-linolenic acid (18:3n-3) were released significantly faster than average. There was no relationship between the rate of release of a fatty acid and the number of carbons or the number of double bonds. Lipoprotein lipase selectively hydrolyzes the fatty acids of chylomicron triacylglycerols. This selectively will result in remnants that are relatively depleted in 18:0, 20:1, and 18:3 and relatively enriched in 20:5 and 22:6.
研究了心脏脂蛋白脂肪酶对富含长链n-3脂肪酸的乳糜微粒的水解作用。在60分钟内，24.8%的三酰甘油脂肪酸以游离脂肪酸的形式释放出来。脂肪酸以不同的速率被水解。二十二碳六烯酸（DHA，22:6n-3）和二十碳五烯酸（EPA，20:5n-3）的释放速率明显低于平均水平。硬脂酸（18:0）、20:1n-9和α-亚麻酸（18:3n-3）的释放速率明显高于平均水平。脂肪酸的释放速率与碳原子数或双键数之间没有关系。脂蛋白脂肪酶选择性地水解乳糜微粒三酰甘油的脂肪酸。这种选择性将导致乳糜微粒残粒中18:0、20:1和18:3相对减少，而20:5和22:6相对增加。
