Toivola P T, Bridson W E, Robinson J A
Endocrinology. 1978 Jun;102(6):1815. doi: 10.1210/endo-102-6-1815.
Plasma levels of radioimmunoreactive LH, FSH, and testosterone (T) were assayed before and after administration of synthetic gonadotropin-releasing hormone (GnRH) to five chair-restrained rhesus monkeys with chronic indwelling venous catheters. Intravenous injection of 1, 5, and 25 microgram or infusion of 1 microgram/min for 25 min of GnRH resulted in a significant increase in plasma levels of LH. However, no significant increases in plasma FSH levels were detected. Plasma levels of T were also elevated after administration of 25 microgram GnRH, but peak concentration of T lagged behind peak levels of LH by approximately 30 min. These studies indicate that the male rhesus responds to GnRH administration by increased secretion of LH, followed by an increase in T levels. A concomitant increase in plasma FSH was not observed after treatment with GnRH in the doses used.
对五只通过慢性留置静脉导管进行椅式约束的恒河猴，在注射合成促性腺激素释放激素（GnRH）前后测定了放射免疫反应性促黄体生成素（LH）、促卵泡生成素（FSH）和睾酮（T）的血浆水平。静脉注射1、5和25微克的GnRH或以1微克/分钟的速度输注25分钟的GnRH，导致血浆LH水平显著升高。然而，未检测到血浆FSH水平有显著升高。给予25微克GnRH后，血浆T水平也升高，但T的峰值浓度比LH的峰值水平滞后约30分钟。这些研究表明，雄性恒河猴对GnRH给药的反应是LH分泌增加，随后T水平升高。在所使用的GnRH剂量治疗后，未观察到血浆FSH同时增加。
