Xu Z Q, Ma X, Soomets U, Langel U, Hökfelt T
Department of Neuroscience, Karolinska Institute, Stockholm University, S-171 77 Stockholm, Sweden.
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14583-7. doi: 10.1073/pnas.96.25.14583.
The effects of the 29-amino acid neuropeptide galanin [GAL (1-29)], GAL(1-15), GAL(1-16), and the GAL subtype 2 receptor agonist D-tryptophan(2)-GAL(1-29) were studied in the dorsal hippocampus in vitro with intracellular recording techniques. GAL(1-15) induced, in the presence of tetrodotoxin, a dose-dependent hyperpolarization in hippocampal CA3 neurons. Most of the GAL(1-15)-sensitive neurons did not respond to GAL(1-29), GAL(1-16), or D-tryptophan(2)-GAL(1-29). These results indicate the presence of a distinct, yet-to-be cloned GAL(1-15)-selective receptor on CA3 neurons in the dorsal hippocampus.
利用细胞内记录技术在体外对背侧海马体中29个氨基酸的神经肽甘丙肽[GAL(1 - 29)]、GAL(1 - 15)、GAL(1 - 16)以及甘丙肽2型受体激动剂D - 色氨酸(2)-GAL(1 - 29)的作用进行了研究。在存在河豚毒素的情况下,GAL(1 - 15)在海马体CA3神经元中诱导出剂量依赖性超极化。大多数对GAL(1 - 15)敏感的神经元对GAL(1 - 29)、GAL(1 - 16)或D - 色氨酸(2)-GAL(1 - 29)无反应。这些结果表明,在背侧海马体的CA3神经元上存在一种独特的、尚未克隆的GAL(1 - 15)选择性受体。