Spencer K
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex, RM3 0BE, U.K.
Prenat Diagn. 1999 Nov;19(11):1065-6. doi: 10.1002/(sici)1097-0223(199911)19:11<1065::aid-pd695>3.0.co;2-r.
In an analysis of 3111 singleton pregnancies routinely screened in the first trimester with nuchal translucency, free beta hCG and pregnancy associated plasma protein A (PAPP-A) smoking has been found to occur in 20.8 per cent of pregnant women. When the individual marker levels were assessed in smokers and non-smokers, levels of PAPP-A were reduced in smokers by some 15 per cent. Despite free beta hCG levels being reduced by 10-14 per cent in the second trimester of smoking women, in the first trimester period this is not evident. Simulation studies would suggest that in smokers the detection of trisomy 21 using free beta hCG, PAPP-A and maternal age will be reduced by some 5 to 6 per cent compared with that of the general population.
在一项对3111例单胎妊娠的分析中，这些妊娠在孕早期常规接受了颈部透明带、游离β-人绒毛膜促性腺激素（β-hCG）和妊娠相关血浆蛋白A（PAPP-A）筛查，结果发现20.8%的孕妇吸烟。当对吸烟者和非吸烟者的个体标志物水平进行评估时，吸烟者的PAPP-A水平降低了约15%。尽管吸烟女性在孕中期游离β-hCG水平降低了10%至14%，但在孕早期这一情况并不明显。模拟研究表明，与普通人群相比，吸烟者使用游离β-hCG、PAPP-A和孕妇年龄检测21三体综合征的检出率将降低约5%至6%。
