Vidalain P O, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
Laboratoire d'Immunobiologie Fondamentale et Clinique, INSERM U503, ENS de Lyon, 69364 Lyon Cedex 07, France.
J Virol. 2000 Jan;74(1):556-9. doi: 10.1128/jvi.74.1.556-559.2000.
Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.
麻疹病毒感染会引发严重的免疫抑制,进而导致严重的继发性感染。在此我们证明,麻疹病毒可诱导人单核细胞衍生的树突状细胞中肿瘤坏死因子相关凋亡诱导配体(TRAIL)的mRNA和蛋白质表达。此外,感染麻疹病毒的树突状细胞通过TRAIL途径表现出细胞毒性。