脊髓损伤后肌纤维类型特异性肌原纤维Ca(2+)ATP酶活性
Muscle fiber type-specific myofibrillar Ca(2+) ATPase activity after spinal cord injury.
作者信息
Castro M J, Apple D F, Melton-Rogers S, Dudley G A
机构信息
Department of Exercise Science, The University of Georgia, 115F Ramsey Student Center, 300 River Road, Athens, Georgia 30602, USA.
出版信息
Muscle Nerve. 2000 Jan;23(1):119-21. doi: 10.1002/(sici)1097-4598(200001)23:1<119::aid-mus17>3.0.co;2-z.
Biopsies of the vastus lateralis muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar Ca(2+) adenosine triphosphate activity (qATPase), contributes to greater fatigue in affected muscle of spinal cord injured (SCI) patients. The qATPase activity showed a fiber-type effect, IIax + IIx > IIa > I. Average fiber qATPase and fiber specific qATPase activities were not different between SCI and able-bodied controls, nor did they change over time. We suggest greater fatigue in SCI subjects early after injury does not reflect increased energy demand of contraction.
对股外侧肌活检样本进行分析，以确定肌原纤维Ca(2+)三磷酸腺苷酶活性（qATP酶）间接反映的收缩能量需求增加是否会导致脊髓损伤（SCI）患者受累肌肉出现更严重的疲劳。qATP酶活性呈现纤维类型效应，即IIax + IIx > IIa > I。SCI患者与健全对照者之间的平均纤维qATP酶和纤维特异性qATP酶活性并无差异，且随时间也未发生变化。我们认为，SCI患者在损伤后早期出现的更严重疲劳并非反映收缩能量需求增加。
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