用醋酸可的松治疗前后，狗在注入可的松后血浆皮质醇浓度。
Plasma cortisol concentrations following cortisone infusion in dogs before and after treatment with cortisone acetate.
作者信息
Church D B, Emslie D R, Watson A D
机构信息
Department of Veterinary Clinical Sciences, University of Sydney, New South Wales.
出版信息
Aust Vet J. 1999 Oct;77(10):671-3. doi: 10.1111/j.1751-0813.1999.tb13163.x.
OBJECTIVE
To evaluate effects of iatrogenic hyperadrenocorticism on plasma cortisol concentrations produced by an infusion of hydrocortisone in dogs.
PROCEDURE
Plasma cortisol concentrations were measured regularly during a 6 h infusion of hydrocortisone sodium succinate at two dose rates. The infusions were performed before and after treatment for 30 d with oral cortisone acetate at 10 mg/kg/24 h, divided thrice daily. Adrenal activity during the experimental period was assessed by weekly ACTH stimulation tests.
RESULTS
Both infusion rates produced lower plasma cortisol concentrations after treatment for 30 d with cortisone.
CONCLUSION
Prior exposure to high concentrations of glucocorticoids may result in accelerated metabolism of glucocorticoids administered subsequently. This may necessitate increased dosages when using glucocorticoids to support inadequate adrenal function.
目的
评估医源性肾上腺皮质功能亢进对犬输注氢化可的松所产生的血浆皮质醇浓度的影响。
程序
在以两种剂量速率输注氢化可的松琥珀酸钠的6小时期间，定期测量血浆皮质醇浓度。输注在以10mg/kg/24小时口服醋酸可的松治疗30天之前和之后进行，每日分三次服用。通过每周的促肾上腺皮质激素刺激试验评估实验期间的肾上腺活性。
结果
两种输注速率在使用可的松治疗30天后均产生较低的血浆皮质醇浓度。
结论
先前暴露于高浓度糖皮质激素可能导致随后给予的糖皮质激素代谢加速。在使用糖皮质激素支持肾上腺功能不足时，这可能需要增加剂量。
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