血液学和恶性疾病患儿的血清溶菌酶活性

Serum lysozyme activity in children with hematological and malignant disorders.

作者信息

Moe P J, Haneberg B, Finne P H

出版信息

Acta Paediatr Scand. 1975 Nov;64(6):830-2. doi: 10.1111/j.1651-2227.1975.tb03932.x.

DOI:10.1111/j.1651-2227.1975.tb03932.x

Abstract

Pretreatment serum lysozyme activity was high in 2 children with myelomonocytic leukemia, 800 and 1 000 mug/ml, normal in all 10 cases of acute lyelocytic leukemia and subnormal in 21 of 34 cases of acute lymphocytic leukemia. Normal values were found in all but one case of acute lymphocytic leukemia during complete remission including 8 cases after all therapy had been discontinued. All 8 are still in complete remission. Low serum lysozyme activity was found in 5 patients with acute lymphocytic leukemia in complete relapse, this could possibly be helpful in the diagnosis of early relapse. Activity was subnormal in 5 of 17 children with malignant tumours, and in 3 of 65 cases of various benign hematological disorders.

摘要

2例骨髓单核细胞白血病患儿治疗前血清溶菌酶活性较高，分别为800和1000微克/毫升；10例急性粒细胞白血病患儿血清溶菌酶活性均正常；34例急性淋巴细胞白血病患儿中有21例血清溶菌酶活性低于正常。除1例急性淋巴细胞白血病患儿外，其余所有处于完全缓解期的急性淋巴细胞白血病患儿（包括8例停止所有治疗后的患儿）血清溶菌酶活性均正常。这8例患儿仍处于完全缓解期。5例急性淋巴细胞白血病完全复发患儿血清溶菌酶活性较低，这可能有助于早期复发的诊断。17例恶性肿瘤患儿中有5例血清溶菌酶活性低于正常，65例各种良性血液系统疾病患儿中有3例血清溶菌酶活性低于正常。