Bratlid D, Moe P J
Eur J Pediatr. 1978 Apr 20;127(4):263-8. doi: 10.1007/BF00493542.
Serum lysozyme activity was measured in samples from children with acute leukemia, malignant tumours, and in normal children. All children with acute lymphatic leukemia (ALL) had significantly reduced levels of lysozyme at diagnosis, and none of the children fell within the normal range. Children with ALL in complete remission had lysozyme levels comparable to normal chidren, while children with ALL in relapse also had pathological low levels. Children with ALL in remission and off therapy also had normal levels of lysozyme. Children with acute myelogenous leukemia had normal lysozyme levels, while children with monomyelocytic leukemia had substantially elevated lysozyme levels before treatment. Determination of serum lysozyme activity in children with acute leukemia is of value both for diagnosis and for evaluating the effect of therapy.
对患有急性白血病、恶性肿瘤的儿童以及正常儿童的样本进行了血清溶菌酶活性检测。所有急性淋巴细胞白血病（ALL）患儿在诊断时溶菌酶水平均显著降低，且无一例患儿的溶菌酶水平处于正常范围。完全缓解的ALL患儿的溶菌酶水平与正常儿童相当，而复发的ALL患儿溶菌酶水平也处于病理性低水平。缓解期且停止治疗的ALL患儿溶菌酶水平也正常。急性髓性白血病患儿的溶菌酶水平正常，而单核细胞白血病患儿在治疗前溶菌酶水平大幅升高。测定急性白血病患儿的血清溶菌酶活性对诊断和评估治疗效果均有价值。
