Doyle J L, Manhold J H
J Dent Res. 1975 Nov-Dec;54(6):1196-9. doi: 10.1177/00220345750540061601.
Feulgen microspectrophotometry was performed using the two wavelength method on 33 lesions and showed that five of ten carcinomas and 12 of 16 leukoplakias had diploid cell lines. This correlates well with similar findings in cervical cancer and dysplasia suggesting that changes in nuclear deoxyribonucleic acid content occur quite early in the evolution of cancer.
采用双波长法对33个病变组织进行福尔根显微分光光度测定，结果显示，10例癌中有5例以及16例白斑中有12例存在二倍体细胞系。这与宫颈癌及发育异常的类似发现高度相关，提示细胞核脱氧核糖核酸含量的变化在癌症发展过程中很早就已出现。
