The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice.
作者信息
Giraldo P, Giménez E, Montoliu L
机构信息
Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología, Madrid, Spain.
出版信息
Genet Anal. 1999 Nov;15(3-5):175-8. doi: 10.1016/s1050-3862(99)00023-6.
Abstract
Variegation and inherited somatic mosaicism has been observed in transgenic mice carrying yeast artificial chromosomes (YACs) in which a DNAse I hypersensitive site (HS) located -12 kb upstream of the mouse tyrosinase gene had been deleted. At present, we are generating new transgenic animals with minor deletions of the HS.
摘要
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