Aragaki C, Quiaoit F, Hsu L, Zhao L P
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Genet Epidemiol. 1999;17 Suppl 1:S43-8. doi: 10.1002/gepi.1370170708.
Using a recently developed semiparametric method for combined linkage/linkage-disequilibrium analysis, we analyzed the Collaborative Study on the Genetics of Alcoholism data subset developed for Genetic Analysis Workshop 11 (GAW11). This semiparametric approach estimates recombination fractions for linkage, marker log odds ratios for linkage-disequilibrium, their product for combined linkage/linkage-disequilibrium, and corresponding z-scores. We used two outcomes: alcohol dependence and "alcoholism-free" and a genome-wide significance level of 4.1 (which corresponds to a genome-wide lod score of 3.6). For the alcohol dependence outcome, we observed significant linkage signals at D1S1588-D1S1631, D1S547, D2S399, D2S425, D4S2361, D7S1796, and D7S1824. We also found significant linkage-disequilibrium signals at D1S547 and D7S1795. For the "alcoholism-free" outcome, we found significant linkage signals at D4S2457, D41651 (both flank ADH3), D11S2359, and D16S47 and significant linkage-disequilibrium signals at D4S2361, FABP2, D11S2359, D19S431 and D19S47-D19S198-D19S601.
我们使用一种最近开发的用于联合连锁/连锁不平衡分析的半参数方法，对为遗传分析研讨会11（GAW11）开发的酒精中毒遗传学合作研究数据子集进行了分析。这种半参数方法估计连锁的重组分数、连锁不平衡的标记对数优势比、联合连锁/连锁不平衡的乘积以及相应的z分数。我们使用了两个结果：酒精依赖和“无酒精中毒”，以及全基因组显著性水平4.1（对应全基因组lod分数3.6）。对于酒精依赖结果，我们在D1S1588 - D1S1631、D1S547、D2S399、D2S425、D4S2361、D7S1796和D7S1824处观察到显著的连锁信号。我们还在D1S
