Pal'tsev M A, Zolotarevskiĭ V B, Ivanov A A, Vetshev P S, Baranova O V, Gabaidze G I
I. M. Sechenov Moscow Medical Academy, Moscow.
Arkh Patol. 1999 Sep-Oct;61(5):46-51.
As shown by a semiquantitative analysis of histological changes in the thyroid tissue, there is a correlation between some characteristic features of autoimmune thyroiditis (Hashimoto's thyroiditis). Formation of lymphoid nodules in the thyroid in autoimmune thyroiditis was followed up and its three stages were distinguished. Autoimmune thyroiditis has three degrees of activity by diffuse lymphoid-plasmocytic infiltration, thyroid tissue destruction and lymphoid nodules formation. Differences between autoimmune thyroiditis and focal thyroiditis are revealed. The above differences include spread and cellular composition, content of the lymphoid-plasmocytic infiltrate, the degree of the destructive changes, B-cell hyperplasia, expression of CD-4 on T-helpers and CD-19 on B-lymphocytes, cytological picture. These differences allow differential diagnosis between these diseases.
甲状腺组织组织学变化的半定量分析表明，自身免疫性甲状腺炎（桥本甲状腺炎）的某些特征之间存在相关性。对自身免疫性甲状腺炎中甲状腺内淋巴小结的形成进行了随访，并区分了其三个阶段。自身免疫性甲状腺炎根据弥漫性淋巴细胞 - 浆细胞浸润、甲状腺组织破坏和淋巴小结形成有三个活动度。揭示了自身免疫性甲状腺炎与局灶性甲状腺炎之间的差异。上述差异包括病变范围和细胞组成、淋巴细胞 - 浆细胞浸润的含量、破坏程度、B细胞增生、T辅助细胞上CD - 4和B淋巴细胞上CD - 19的表达、细胞学表现。这些差异有助于对这些疾病进行鉴别诊断。
