Suppr超能文献

[首次精神病发作的治疗策略]

[Therapeutic strategies in the first psychotic episode].

作者信息

Douki S, Taktak M J, Ben Zineb S, Cheour M

机构信息

Service de Psychiatrie, Hôpital Razi, La Manouba, Tunis, Tunisie.

出版信息

Encephale. 1999 Nov;25 Spec No 3:44-51.

Abstract

A first psychotic episode includes a wide range of disorders with different outcomes: schizophrenia, bipolar disorder, schizophreniform disorder, schizoaffective disorder, drug-induced psychosis, brief reactive psychosis, organic psychoses and delusional disorder. The course and outcome of a first psychotic episode is greatly dependent on its initial management. Major clinical, etiopathogenic and therapeutic advances have been achieved in this field and have allowed specific management strategies to be adopted. The primary task of therapists involved in the management of patients who have experienced a first episode of psychosis is promotion of recovery and prevention of secondary morbidity, relapse and persistent disability. The main guidelines of an early psychosis management are:--to keep in mind that early psychosis is not early schizophrenia. Thus, clinicians and therapists should avoid an early diagnosis of schizophrenia. Diagnosis in early psychosis can be highly unstable. A diagnosis of schizophrenia, with its implications of pessimism, relapse and disability, does not contribute anything positive in terms of guiding treatment. On the contrary, such a diagnosis may damage the patient and family by stigmatizing them and affecting the way they are viewed and managed by healthcare professionals.--To integrate biological, psychological and social interventions: effective medications is useful in reducing the risk of relapse, but is not a guarantee against it. Psychological and social interventions can greatly help promote recovery.--To tailor the various strategies to met the needs of an individual: as an example, it is important to formulate appropriate strategies for the different stages of the illness (prodromal phase, acute phase, early recovery phase and late recovery phase) because patients have different therapeutic needs at each stage.--In the acute treatment, not to concentrate on short-term goals in indicating antipsychotic treatment: prescribing principles for first-episode psychosis are to maximise benefit and minimise side effects because the first experience of medication may influence a patient's future attitudes of therapy of all types. Effective strategies which may reduce long-term morbidity and improve recovery are currently available but their implementation is too often delayed. The time lag between the onset of symptoms and the start of treatment can be many months or years and this delay can have serious consequences. The critical period of the first 2-5 years after the first psychotic episode is a time of maximum vulnerability and of maximum opportunity. Consequently, actions should be undertaken to promote early recognition and assistance in psychotic disorders: understanding of the factors that may cause delay in treatment can help minimise this problem and lead to the initiation of appropriate treatment at the earliest opportunity. Training the general practitioners who have an important part to play in the early recognition is also of crucial importance.

摘要

首次精神病发作包括一系列具有不同转归的疾病

精神分裂症、双相情感障碍、精神分裂症样障碍、分裂情感性障碍、药物所致精神病、急性反应性精神病、器质性精神病和妄想性障碍。首次精神病发作的病程和转归在很大程度上取决于其初始治疗。该领域已取得了重大的临床、病因学和治疗进展,并已允许采用特定的治疗策略。参与首次精神病发作患者治疗的治疗师的主要任务是促进康复并预防继发性疾病、复发和持续性残疾。早期精神病治疗的主要指导原则如下:

  • 要记住早期精神病并非早期精神分裂症。因此,临床医生和治疗师应避免过早诊断为精神分裂症。早期精神病的诊断可能极不稳定。精神分裂症的诊断带有悲观、复发和残疾的意味,在指导治疗方面并无任何积极作用。相反,这样的诊断可能会给患者及其家庭带来伤害,因为会给他们贴上污名标签,并影响医护人员对他们的看法和治疗方式。

  • 整合生物、心理和社会干预措施:有效的药物治疗有助于降低复发风险,但不能保证预防复发。心理和社会干预措施可极大地促进康复。

  • 根据个体需求调整各种策略:例如,为疾病的不同阶段(前驱期、急性期、早期康复期和后期康复期)制定适当的策略很重要,因为患者在每个阶段有不同的治疗需求。

  • 在急性治疗中,在开具抗精神病药物治疗时不要只关注短期目标:首次发作精神病的处方原则是使益处最大化并使副作用最小化,因为首次用药体验可能会影响患者对所有类型治疗的未来态度。目前已有可降低长期发病率并改善康复的有效策略,但它们的实施往往被推迟。症状出现与开始治疗之间的时间间隔可能长达数月或数年,这种延迟可能会产生严重后果。首次精神病发作后的头2至5年是最脆弱且机会最大的关键时期。因此,应采取行动促进对精神病性障碍的早期识别和救助:了解可能导致治疗延迟的因素有助于将这一问题降至最低,并尽早开始适当治疗。培训在早期识别中起重要作用的全科医生也至关重要。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验