Krebs M-O, Lejuste F, Martinez G
Centre dévaluation du jeune adulte et adolescent (C'JAAD), Service Hospitalo-Universitaire - S14, Centre hospitalier Sainte-Anne, Paris, France; Inserm U894 centre de psychiatrie et neurosciences, institut de psychiatrie (CNRS GDR 3557) www.institutdepsychiatrie.org, France.
Centre dévaluation du jeune adulte et adolescent (C'JAAD), Service Hospitalo-Universitaire - S14, Centre hospitalier Sainte-Anne, Paris, France; Inserm U894 centre de psychiatrie et neurosciences, institut de psychiatrie (CNRS GDR 3557) www.institutdepsychiatrie.org, France.
Encephale. 2018 Dec;44(6S):S17-S20. doi: 10.1016/S0013-7006(19)30073-9.
Early detection and early intervention programs in early adolescent and young adult psychosis have developed in many countries and have shown their effectiveness. The main lesson of these programs is to have demonstrated that the progression of at-risk mental state into to a full-blown psychosis or of a psychotic episode to a chronic schizophrenic disorder is evitable. They have also shown that the earlier appropriate care is set up the better the functional remission and that the period of "early psychosis" encompassing the period preceding the emergence of psychosis and the first months after the first psychotic episode, is a period of opportunity for a preventive or curative intervention. Specialized therapeutic strategies shall include patient's centered integrative care. According to international recommendations, early intervention provides an extensive multidisciplinary assessment in search of possible organic etiologies and in instrumental to adapt care strategies to the person's need. It helps to identify levers for a psychosocial approach (psychoeducation, cognitive and behavioral therapies, cognitive remediation, case management) and for adressing aggravating factors (substance use, family interventions, educational support, etc.). A second-generation antipsychotic should be introduced, at lower doses than for a chronic disorder. The young patient must be accompanied until recovery by a specialized multidisciplinary team, usually for a period of 2 to 3 years. Deployment of such programs is a societal challenge and represents a paradigm shift: it questions the practices and organization of the healthcare system, but also the way healthcare professionals and the general public look at these diseases. In France, the Transition Network, a founding member of the French-speaking branch of IEPA, aims to facilitate the dissemination of these practices on a National scale, and to help to harmonize emerging initiatives.
许多国家都开展了针对青少年早期和青年期精神病的早期检测与早期干预项目,并已证明其有效性。这些项目的主要经验教训在于,已证实处于风险中的精神状态发展为全面精神病或精神病发作发展为慢性精神分裂症是可以避免的。它们还表明,越早建立适当的治疗,功能缓解就越好,而涵盖精神病出现前阶段和首次精神病发作后的头几个月的“早期精神病”时期,是进行预防性或治愈性干预的机会期。专门的治疗策略应包括以患者为中心的综合护理。根据国际建议,早期干预提供广泛的多学科评估,以寻找可能的器质性病因,并有助于根据个人需求调整护理策略。它有助于确定心理社会方法(心理教育、认知行为疗法、认知康复、病例管理)的杠杆以及应对加重因素(物质使用、家庭干预、教育支持等)的杠杆。应引入第二代抗精神病药物,剂量低于治疗慢性疾病时的剂量。年轻患者必须在一个专业的多学科团队陪伴下直至康复,通常为期2至3年。开展此类项目是一项社会挑战,代表着一种范式转变:它不仅质疑医疗保健系统的做法和组织,也质疑医疗保健专业人员和公众看待这些疾病的方式。在法国,过渡网络是国际早期精神病协会法语区的创始成员之一,旨在促进这些做法在全国范围内的传播,并帮助协调新出现的倡议。