Walters M C
Fred Hutchinson Cancer Research Center and the Department of Pediatrics, University of Washington School of Medicine, Seattle, USA.
J Pediatr Hematol Oncol. 1999 Nov-Dec;21(6):467-74. doi: 10.1097/00043426-199911000-00005.
Bone marrow transplantation has curative potential for patients who have sickle cell disease. However, concerns about short-term and long-term toxicity, lack of suitable stem cell donors, and limited access to this treatment currently make it an infrequently utilized treatment for sickle cell disease. The current results of bone marrow transplantation for sickle cell disease and barriers to wider application are reviewed. Strategies that might lead to broader availability and reduced toxicity of bone marrow transplantation are discussed.
骨髓移植对患有镰状细胞病的患者具有治愈潜力。然而，对短期和长期毒性的担忧、缺乏合适的干细胞供体以及目前获得这种治疗的机会有限，使得它目前很少用于镰状细胞病的治疗。本文综述了镰状细胞病骨髓移植的当前结果以及更广泛应用的障碍。还讨论了可能导致骨髓移植更广泛可用和毒性降低的策略。
