Cui Y, Urschel J D, Petrelli N J
Department of Thoracic Surgery, Roswell Park Cancer Institute, and State University of New York at Buffalo, USA.
J Invest Surg. 1999 Sep-Oct;12(5):295-8. doi: 10.1080/089419399272412.
Esophagectomy with esophagogastric anastomosis is not uncommonly complicated by anastomotic dehiscence. Although this is a major problem in clinical esophageal surgery, laboratory investigation of esophagogastric anastomotic wound healing has been hampered by the lack of a practical rodent model. Researchers have turned to large-animal experiments, or used various upper gastrointestinal pseudo-anastomotic techniques in rodents. None of these approaches has proved to be satisfactory. We report our technique of side-to-side esophagogastric anastomosis in the rat. Using this technique we have overcome the problems encountered in our earlier studies of esophagogastric anastomotic wound healing in the rat.
食管胃吻合术式的食管癌切除术常并发吻合口裂开。尽管这是临床食管手术中的一个主要问题，但由于缺乏实用的啮齿动物模型，食管胃吻合口愈合的实验室研究受到了阻碍。研究人员转而进行大型动物实验，或在啮齿动物中使用各种上消化道假吻合技术。但这些方法都不尽人意。我们报告了大鼠食管胃侧侧吻合术的技术。使用该技术，我们克服了早期大鼠食管胃吻合口愈合研究中遇到的问题。
