Azzopardi C, Montefort S, Mallia C
Department of Medicine, St. Luke's Hospital, Guardamangia, Malta.
Adv Exp Med Biol. 1999;455:547-9. doi: 10.1007/978-1-4615-4857-7_82.
The Churg-Strauss syndrome is characterised by a history of asthma and paranasal sinus disease, eosinophilia of more than 10 per cent, non-fixed pulmonary infiltrates on chest radiography and vasculitis which may affect multiple organ systems. The condition usually manifests in the 4th decade. We present a 21-year old female with a history of asthma since one year of age who developed symptoms and signs of pneumonia, a pulmonary infiltrate on chest radiography and eosinophilia. This was followed a few weeks later by vasculitis which affected the skin and myocardium and associated with a peripheral eosinophilia of more than 80%. Physical examination revealed palpable purpura and signs of left ventricular failure. Echocardiography confirmed significant diminution of left ventricular contractility. A rapid improvement was observed after steroid therapy. Echocardiography after two months showed normal left ventricular function. In this presentation we review the cardiac manifestations of the Churg-Strauss syndrome and its management.
变应性肉芽肿性血管炎以哮喘病史、鼻旁窦疾病、嗜酸性粒细胞增多超过10%、胸部X线片显示非固定性肺部浸润以及可能累及多个器官系统的血管炎为特征。该病通常在40岁左右出现。我们报告一名21岁女性，自1岁起有哮喘病史，出现肺炎症状和体征、胸部X线片显示肺部浸润及嗜酸性粒细胞增多。几周后出现累及皮肤和心肌的血管炎，并伴有外周血嗜酸性粒细胞增多超过80%。体格检查发现可触及的紫癜及左心室衰竭体征。超声心动图证实左心室收缩力明显减弱。类固醇治疗后病情迅速改善。两个月后的超声心动图显示左心室功能正常。在本报告中，我们回顾了变应性肉芽肿性血管炎的心脏表现及其治疗。
