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[一名病态肥胖患者的脂肪性肝硬化]

[Steatohepatic cirrhosis in a morbidly obese patient].

作者信息

Kohan M, López D, Botto G, Alessio C

机构信息

Hospital General de Agudos Dr. Teodoro Alvarez, Gobierno de la Ciudad de Buenos Aires. /Cirrhotic steatopatitis in a morbidly obese patient/

出版信息

Acta Gastroenterol Latinoam. 1999;29(4):271-5.

Abstract

Sixty to ninety percent of obese subjects show histological abnormalities of the liver. The hepatic lesion can be classified into one of the four following groups: steatosis, steatohepatitis, fibrosis and cirrhosis. The incidence of cirrhosis among patients with fatty liver changes ranges from 1.5% to 8%. The now abandoned surgery procedures performed for the treatment of morbid obesity (jejunoileal bypass) had left a negative experience: the onset of acute hepatic failure in subjects with no previous hepatic disease or the development of cirrhosis within one year of the bypass. Very low formula diets leading to precipitous weight loss in morbidly obese people induce metabolic changes similar to those observed after jejunoileal bypass. We report the case of a morbidly obese patient who had lost 40 kg of weight during the 6 months previous to his hospitalization. He came with signs of hepatic failure. He worsened rapidly and died in a month-time. The hepatic tissue obtained post-mortem showed a non alcoholic steatohepatitic cirrhosis.

摘要

60%至90%的肥胖受试者存在肝脏组织学异常。肝脏病变可分为以下四类之一:脂肪变性、脂肪性肝炎、纤维化和肝硬化。脂肪肝改变患者中肝硬化的发生率为1.5%至8%。过去用于治疗病态肥胖的手术方法(空肠回肠分流术)已不再使用,因为它留下了负面经验:既往无肝病的受试者出现急性肝衰竭,或在分流术后一年内发展为肝硬化。极低热量配方饮食导致病态肥胖者体重急剧下降,会引发与空肠回肠分流术后类似的代谢变化。我们报告一例病态肥胖患者,其在住院前6个月内体重减轻了40公斤。他因肝衰竭症状前来就诊。病情迅速恶化,一个月后死亡。尸检获得的肝组织显示为非酒精性脂肪性肝炎肝硬化。

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