McFerrin J, Engel W K, Askanas V
USC Neuromuscular Center, Department of Neurology, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles 90017-1912, USA.
Neurology. 1999 Dec 10;53(9):2184-7. doi: 10.1212/wnl.53.9.2184.
Cultured muscle fibers from patients with sporadic inclusion-body myositis (s-IBM), similar to normal control muscle fibers, 1) did not have beta-amyloid precursor protein (betaAPP) immunoreactivity; and 2) became normally innervated, as evidenced by the following features: full cross-striation, continuous contraction, and acetylcholinesterase and acetylcholine receptors accumulated only at neuromuscular junctions. Thus, factors responsible for betaAPP accumulation and denervation-like changes in s-IBM muscle biopsies are not operative in the relatively short-term, non-aged, cultured s-IBM muscle fibers.
散发性包涵体肌炎（s-IBM）患者的培养肌纤维，与正常对照肌纤维相似，1）没有β-淀粉样前体蛋白（βAPP）免疫反应性；2）神经支配正常，表现为以下特征：横纹完整、持续收缩，且乙酰胆碱酯酶和乙酰胆碱受体仅在神经肌肉接头处聚集。因此，导致s-IBM肌肉活检中βAPP积累和去神经样改变的因素，在相对短期、未老化的培养s-IBM肌纤维中不起作用。
