Masson R, Fière D, Lahnèche B, Cordat C, Berger F, Revol L
Nouv Presse Med. 1975 Oct 18;4(35):2499-502.
The authors report two cases, the first pathological and the second clinical of pseudo-tumoural cerebral toxoplasmosis, occurring during the course of blood diseases. They refer to the conditions of appearance of this rare complication, with only twenty cases recorded in the literature, during malignant blood diseases. They stress the primordial role of immunological deficiency related either to the underlying disease (especially Hodgkin's disease) or to immuno-suppressive therapy. The clinical picture, with little in the way of typical features, is thus that of a diffuse méningo-encéphalitis. Pseudo-tumoural forms are rare. The authors also stress the minimum conditions required for the validity of the dye test and the value of the diagnosis of cerebral toxoplasmosis. An association of sulphadiazine-purimethamine, active and effective, cured the second patient.
作者报告了两例病例，第一例为血液疾病病程中发生的假性肿瘤性脑弓形虫病的病理学病例，第二例为临床病例。他们提及了这种罕见并发症出现的情况，在恶性血液疾病中，文献中仅记录了20例。他们强调了与基础疾病（尤其是霍奇金病）或免疫抑制治疗相关的免疫缺陷的首要作用。临床表现缺乏典型特征，因而呈现为弥漫性脑膜脑炎。假性肿瘤形式罕见。作者还强调了染色试验有效性所需的最低条件以及脑弓形虫病诊断的价值。磺胺嘧啶 - 乙胺嘧啶联合使用，有效且治愈了第二例患者。
