Hashimoto S i, Ozaki A
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co Ltd, Machida-shi, 194-8533, Japan.
Curr Opin Biotechnol. 1999 Dec;10(6):604-8. doi: 10.1016/s0958-1669(99)00041-5.
The development of recombinant DNA technology has greatly expanded whole microbial cell processes for manufacturing amino acids, vitamins, or ribonucleotides. A novel well-designed scheme with integrated enzymatic conversions and fermentation enables the production of even complicated compounds, such as sugar nucleotides and oligosaccharides.