Mlodzik M
EMBL, Developmental Biology Programme, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
EMBO J. 1999 Dec 15;18(24):6873-9. doi: 10.1093/emboj/18.24.6873.
Functional tissues not only polarize their epithelia in the apical-basolateral axis, but also often display a polarity within the plane of the epithelium. In Drosophila, all adult structures are derived from epithelia called imaginal discs and display planar polarization; the eye and the wing are particularly well suited for analysis. Studies of their polarization have identified several conserved genes that regulate both nuclear signaling and cytoskeletal architecture. In particular, the Frizzled (Fz) receptor has been identified as a key component of polarity establishment in all tissues. The Fz signaling pathway and associated events are beginning to be unraveled, shedding light on a novel Wnt/Fz signaling cascade.
功能组织不仅在顶-基轴上使其上皮细胞极化，而且在上皮平面内也常常表现出极性。在果蝇中，所有成虫结构都源自称为成虫盘的上皮组织，并表现出平面极化；眼睛和翅膀特别适合进行分析。对它们极化的研究已经鉴定出几个保守基因，这些基因调节核信号传导和细胞骨架结构。特别是，卷曲蛋白（Fz）受体已被确定为所有组织中极性建立的关键成分。Fz信号通路及相关事件正开始被阐明，为一种新的Wnt/Fz信号级联反应带来了曙光。
