Asymmetric Total Synthesis of Fluvirucinine A(1).
作者信息
Suh YG, Kim SA, Jung JK, Shin DY, Min KH, Koo BA, Kim HS
机构信息
College of Pharmacy, Seoul National University, San 56-1, Shinrim-Dong, Kwanak-Gu, Seoul 151-742 (Korea).
出版信息
Angew Chem Int Ed Engl. 1999 Dec 3;38(23):3545-3547. doi: 10.1002/(sici)1521-3773(19991203)38:23<3545::aid-anie3545>3.3.co;2-s.
Abstract
Diastereoselective vinyl addition to an amide carbonyl group and amide enolate induced aza-Claisen rearrangement are the key steps in the first asymmetric total synthesis of fluvirucinine A(1) (1), the aglycon of fluvirucin A(1). Fluvirucins are a class of macrolactam antibiotics produced by actinomycete strains that show promising biological properties.
摘要
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