氟病毒素A1、A2、B1、B2、B3、B4和B5，对甲型流感病毒有活性的新型抗生素。IV. 产生菌的分类学。

Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. IV. Taxonomy on the producing organisms.

作者信息

Tomita K, Oda N, Hoshino Y, Ohkusa N, Chikazawa H

机构信息

Bristol-Myers Squibb Research Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Sep;44(9):940-8. doi: 10.7164/antibiotics.44.940.

DOI:10.7164/antibiotics.44.940

PMID:1938616

Abstract

The morphology, chemotaxonomy, and cultural and physiological characteristics were examined on the five strains of actinomycetes which produce antiviral antibiotics, fluvirucin congeners. All strains have meso-2,6-diaminopimelic acid in the cell wall. Four strains, Q464-31, L407-5, R359-5 and R516-16, belong to the maduromycetes since they have madurose in the whole cell. The remaining one strain, R869-90, has rhamnose but no madurose, and is a nocardioform actinomycete. These five strains were classified and designated as follows: Strain Q464-31 (fluvirucin A1 producer): Microtetraspora tyrrhenii sp. nov. (Actinomadura pusilla group). Strain L407-5 (fluvirucin B2 producer): A maduromycete. Strain R359-5 (fluvirucin B1 producer): Microtetraspora pusilla (Actinomadura pusilla group). Strain R869-90 (fluvirucin A2 producer): Saccharothrix mutabilis. Strain R516-16 (fluvirucins B2, B3, B4 and B5 producer): A maduromycete.

摘要

对五株产生抗病毒抗生素氟维菌素同系物的放线菌菌株进行了形态学、化学分类学以及培养和生理特征研究。所有菌株细胞壁中均含有内消旋-2,6-二氨基庚二酸。四株菌株Q464-31、L407-5、R359-5和R516-16属于马杜拉放线菌，因为它们的全细胞中含有马杜糖。其余一株菌株R869-90含有鼠李糖但不含马杜糖，属于诺卡氏型放线菌。这五株菌株分类命名如下：菌株Q464-31（氟维菌素A1产生菌）：新种 Tyrrhenii小多孢菌（微小马杜拉放线菌群）。菌株L407-5（氟维菌素B2产生菌）：马杜拉放线菌。菌株R359-5（氟维菌素B1产生菌）：微小马杜拉放线菌（微小马杜拉放线菌群）。菌株R869-90（氟维菌素A2产生菌）：可变糖丝菌。菌株R516-16（氟维菌素B2、B3、B4和B5产生菌）：马杜拉放线菌。