Davis K L, Berger P A, Hollister L E
Psychopharmacol Commun. 1976;2(2):125-30.
Tardive dyskinesia has been regarded as a long-term complication of neuroleptic administration to patients with the diagnosis of schizophrenia. However, nine of the first fourteen patients evaluated for an investigation of tardive dyskinesia met diagnostic criteria for depression. Neuroleptics produce blockade of post-synaptic dopaminergic receptors. Tardive dyskinesia occurs when neuroleptics are discontinued, and is regarded as a manifestation of super-sensitive post-synaptic dopaminergic receptors. Tardive dyskinesia occurs when neuroleptics are discontinued, and is regarded as a manifestation of super-sensitive post-synaptic dopaminergic receptors. Chronically decreased neurotransmission in the synapse of a patient with depression may contribute to the development of a super-sensitive receptor and could explain the high proportion of patients with depression seen in this sample of patients with tardive dyskinesia.
迟发性运动障碍一直被视为对精神分裂症患者使用抗精神病药物的一种长期并发症。然而，在最初接受迟发性运动障碍调查评估的14名患者中，有9名符合抑郁症的诊断标准。抗精神病药物会阻断突触后多巴胺能受体。当停用抗精神病药物时会发生迟发性运动障碍，它被视为突触后多巴胺能受体超敏的一种表现。当停用抗精神病药物时会发生迟发性运动障碍，它被视为突触后多巴胺能受体超敏的一种表现。抑郁症患者突触中神经传递长期减少可能导致超敏受体的形成，这可以解释在这个迟发性运动障碍患者样本中出现的高比例抑郁症患者。
