Lassmann H
Department of Neuroimmunology, University of Vienna, Austria.
Philos Trans R Soc Lond B Biol Sci. 1999 Oct 29;354(1390):1635-40. doi: 10.1098/rstb.1999.0508.
The pathology of multiple sclerosis (MS) was defined more than a century ago as a chronic inflammatory process which is associated with widespread primary demyelination and glial scarring. In this short review we discuss controversial issues on (i) the relationship between inflammation and demyelination, (ii) the various possible mechanisms of myelin destruction, and (iii) axonal involvement in this disease. We suggest that the disease process of MS is more complex that previously believed.
多发性硬化症(MS)的病理学在一个多世纪前就被定义为一种慢性炎症过程,它与广泛的原发性脱髓鞘和胶质瘢痕形成有关。在这篇简短的综述中,我们讨论了以下几个有争议的问题:(i)炎症与脱髓鞘之间的关系;(ii)髓鞘破坏的各种可能机制;以及(iii)该疾病中的轴突受累情况。我们认为,MS的疾病过程比之前认为的更为复杂。